Crop simulation models are increasingly used in agriculture. These models help in saving time and expenses. The objective of this study was to evaluate CropSyst model in predicting development, growth and yield of wheat cultivars from Golestan province. To do this, experimental data from different experiments were gathered for Kohdasht, Shiroodi, Tajan and Zagros. Model performance in simulating days to anthesis and maturity, biomass accumulation at anthesis and maturity and leaf area index at anthesis, nitrogen accumulation at anthesis and maturity and grain yield were evaluated. Root mean square error (RMSE) were 5.2 and 9.5 days for anthesis and maturity that were 4.6% and 6.4% of the means, respectively. RMSE of LAI at anthesis was 1.2 m2.m-2 that was 20.9% of the mean. For grain yield, RMSE was 556 kg.ha-1, 13.3% of mean. For other development and growth characteristics, model performance was acceptable. Therefore, this model can be used in simulation of these cultivars.